ALLOSTERIC MODULATION OF PRIMARY SPECIFICITY OF SERINE PROTEINASES

The selectivity of serine proteinases action is mediated by high-specifice binding the proper parts protein substrate. Among such targets a special place belongs to areas functionally conditioned interaction with active center enzyme. Their sharp difference in enzyme affinity due synchronous and allosteric sites site specific amino acid residues substrate that are adequate specificity placed conformation. This paper devoted consideration manifestation erosion primary proteinases. Examples effects as well possibilities their application discussed.